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desvenlafaxine will enhance the level or influence of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Check. Desvenlafaxine inhibits CYP2D6; with higher desvenlafaxine doses (ie, 400 mg) lessen the CYP2D6 substrate dose by nearly 50%; no dosage adjustment essential with desvenlafaxine doses seven consecutive days immediately prev